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Eomesodermin/README.md

Dillon Corvino, PhD

Computational & wet-lab immunologist · T cell & NK cell biology · Immuno-oncology · Single-cell multi-omics
Postdoctoral Researcher · University Hospital Bonn, Germany


Immunologist with 6+ years of postdoctoral experience across tumour immunology, viral immunity, and translational immuno-oncology. I pair wet-lab expertise in human primary tissue and genetic engineering with independent, end-to-end single-cell and spatial multi-omics analysis — from raw sequencing on HPC through to publication figures. My focus is the biology of cytotoxic lymphocytes and advancing NK/T cell therapy strategies from discovery to the clinic.

🔬 Open to industry roles in immuno-oncology and cell therapy across the EU and Australia.

📊 At a glance

970 citations · h-index 15 · 6+ years postdoc · PI on €110k competitive funding

🧪 What I work on

  • Cytotoxic lymphocyte biology — NK cell plasticity & dysfunction in the tumour microenvironment, CD8 T cell states, unconventional T cells
  • Single-cell & spatial multi-omics — end-to-end scRNA-seq, CITE-seq, scATAC-seq, scTCR-seq and spatial transcriptomics pipelines, run on HPC
  • Cell engineering & therapy — CRISPR KO/KI/OE in primary human NK & CD8 T cells, CAR-NK / CAR-T, preclinical models
  • Translational immunology — reverse-translational discovery, biomarkers, and clinical immune phenotyping from patient tissue

🛠️ Tech

R Python Seurat Bash SLURM Docker Git

📌 Selected repositories

  • lab-protocols — standardised wet-lab & computational protocols
  • Single-cell reanalyses of published immuno-oncology datasets (being made public — check pinned repos)
  • Reproducible scRNA-seq / HPC analysis pipelines and utilities

More work is being surfaced here — see dilloncorvino.com and my pinned repositories.


“Understanding cytotoxic lymphocyte biology, from bench to publication.”

Pinned Loading

  1. r-utility-functions r-utility-functions Public

    R package of reusable bioinformatics & single-cell helper functions (heatmaps, volcano plots, GO, UMAP optimisation, TCGA survival, colour schemes)

    R 1

  2. eomesodermin.github.io eomesodermin.github.io Public

    Source for my academic website — dilloncorvino.com

    HTML

  3. lab-protocols lab-protocols Public

    Standardised wet-lab and computational protocols used by Dillon Corvino

    JavaScript

  4. Thymic_NK_development Thymic_NK_development Public

    Do NK cells carry a thymic TCR footprint, and are CD56bright and CD56dim NK distinct lineages? Single-cell VDJ and somatic mtDNA lineage tracing across public datasets

    Python

  5. nkg7-binder-design nkg7-binder-design Public

    De novo mini-binder design pipeline (RFdiffusion, ProteinMPNN, Boltz-2, Chai-1) applied to NKG7 extracellular loops, with a sequence-complexity audit of the designs

    Python

  6. nkg7-structural-analysis nkg7-structural-analysis Public

    In-silico structural & evolutionary characterisation of NKG7 (cytotoxic-lymphocyte granule tetraspan): structure prediction + homology + pore analysis. Tests the ion-channel hypothesis — finds a se…

    HTML